AML workup
(Haematology)
Investigation : AML workup
Specimen type : BM or PB
Spec container : 4ml EDTA (LAVENDER) 
Volume required : 4 ml
Turnaround : 4 Weeks
Note: Samples referred from outside the RLBUHT should arrive within the laboratory within 72 hours of collection.

Molecular Diagnosis Myeloid Neoplasm Gene Panel Screening:

Test overview: 40 key genes or gene mutation hotspots frequently mutated in myeloid neoplasm and 29 fusion transcripts associated with myeloid neoplasm were screened by using Ion Torrent Oncomine Myeloid Research Assay based on Next Generation Sequencing (NGS) technology.

Genes included in mutation screening:

ABL1, ASXL1, BCOR, BRAF, CALR, CBL, CEBPA, CSF3R, DNMT3A, ETV6, EZH2, FLT3, GATA2, HRAS, IDH1, IDH2, IKZF1, JAK2, KIT, KRAS, MPL, MYD88, NF1, NPM1, NRAS, PHF6, PRPF8, PTPN11, RB1, RUNX1, SETBP1, SF3B1, SH2B3, SRSF2, STAG2, TET2, TP53, U2AF1, WT1, ZRSR2.

Fusion transcripts included in screening:

ABL1, ALK, BCL2, BRAF, CCND1, CREBBP, EGFR, ETV6, FGFR1, FGFR2, FUS, HMGA2, JAK2, KMT2A (MLL), MECOM, MET, MLLT10, MLLT3, MYBL1, MYH11, NTRK3, NUP214, PDGFRA, PDGFRB, RARA, RBM15, RUNX1, TCF3, TFE3.

Contact Molecular Biology Lab for further enquiries on Ext. 4326

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