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BCR-ABL quantitation |
(Haematology) |
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| Investigation | : |
BCR-ABL quantitation | |
| Spec container | : |
4ml EDTA (LAVENDER)
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| Volume required | : |
15ml |
| Turnaround | : |
2 weeks |
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Samples should arrive within the laboratory within 72 hours of collection.
If sample cannot be sent immediately after bleeding, keep in 4 degree fridge and send as soon as possible.
Real-time quantitative RT-PCR for BCR-ABL fusion gene transcripts is used to serially monitor response in patients receiving IFN-a, imatinib (Glivec), other tyrosine kinase inhibitors (TKI) and recipients of allogeneic stem cell transplants (allo-SCT). BCR-ABL transcript levels in the blood correlate strongly with the percentage of Ph- metaphases in the bone marrow. Rising levels of BCR-ABL transcripts is strongly predictive of cytogenetic and haematological relapse.
Contact HODS Molecular Biology Lab for further enquiries on Ext. 4326.
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