||The HLA-B27 antigen is associated with ankylosing spondylitis, juvenile rheumatoid arthritis, and Reiter syndrome. The mechanism of the association is not understood but probably is that of linkage disequilibrium with an as yet unknown causative gene
There is an increased prevalence of HLA-B27 in certain rheumatic diseases, particularly ankylosing spondylitis. HLA-B27 is present in approximately 89% of patients with ankylosing spondylitis, and 42% of patients with juvenile rheumatoid arthritis. Approximately 8% of the normal population carry the HLA-B27 antigen.
Twin and family studies have shown a strong association between susceptibility to Uveitis and the HLA-B*27 gene. HLA-B27 positive relatives of Uveitis patients are at higher risk of developing the disease than B27 positive individuals without an affected relative. However not all B27 positive individuals develop Uveitis, showing that HLA-B27 is often necessary but is not a sufficient genetic predisposing factor for the disease.
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