Investigation : PINP
Specimen type : Serum
Spec container : Serum Gel 
Volume required : 5 ml
Turnaround : <7 days

Clinical Use: P1NP reflects osteoblast activity so any disease increasing the activity of osteoblasts or activation frequency of the bone forming unit will result in elevated P1NP concentrations. Low P1NP may indicate adynamic bone. P1NP is useful in monitoring response to anti-resorption therapy.

Patient preparation: None. P1NP shows minimal circadian rhythm or seasonal variation and food intake or diet show no detectable influence on serum levels. A baseline pre-treatment measurement is required if assessing response to antiresorption therapy.

Sample requirements: Lithium heparin plasma, EDTA plasma or serum. Send by first class post avoiding weekends. Minimum sample requirement - 0.5 ml serum/plasma.

Reference ranges
Pre menopausal Females30 - 78µg/l
Post Menopausal Females26 -110µg/l
Males20 -76µg/l

Additional information on P1NP and its clinical use can be found here: P1NP.

ICE requesting info:ICE panel nameICE page nameColumnComment\Advice
Chem / Haem
Bone Metab


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