Post- haematopoietic stem cell transplant monitoring (chimerism analysis)

(H & I)

Investigation	:	Post- haematopoietic stem cell transplant monitoring (chimerism analysis)

Investigations	Post- haematopoietic stem cell transplant monitoring (chimerism analysis)
Inform lab before sending	Required. This test is manually intensive so the laboratory requires advance notice to allow for effective workload management
Specimen type	Patient: Up to 40ml EDTA required depending on the white cell count of the patients. If unsure users are encouraged to contact the laboratory prior to taking the sample. Alternatively chimerism monitoring can be undertaken on bone marrow aspirate
Ideal time to take specimen	The laboratory requests that samples arrive in the laboratory by 12pm so that DNA can be extracted on the same working day.
Labelling requirements	click here
How to take the specimen	Whole blood into EDTA
Transport to the laboratory	see H&I General Information Page
Test Times	As clinically indicated
Turnround	7 days. This test is monitored as a laboratory performance indicator.
Additional information	Post-transplant chimerism monitoring can be performed on whole blood or bone marrow aspirate samples. The user can also request lineage specific chimerism analysis to be undertaken, usually in the form of T-cell (CD3) lineage specific chimerism analysis.
Additional Examination Requests	A primary sample must be received for this test

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