Cytomegalovirus (CMV)
(Microbiology)
Investigations Cytomegalovirus (CMV)
Human herpes viruses are widespread. Cytomegalovirus infection is usually a mild syndrome in the young but the virus can cause infectious mononucleosis like syndrome in young adults, or severe disease in immunocompromised patients.
Primary CMV infection in pregnant women can be associated with transmission to the foetus in up to 40% of cases.

Serology should not be requested for isolated transaminitis without features of mononucleosis, or on immunocompromised patients.
Serology Tests
CMV IgG / Avidity
CMV IgM

Molecular
CMV PCR
Inform lab before sending No, except for URGENT SAMPLES. Contact the laboratory on 0151 706 4410 to request urgent testing, including pre-transplant serology screening. The laboratory will aim to process urgent CMV PCR samples received in the laboratory before 9am the same day, otherwise, the sample will be processed the next working day.
Specimen type Serology
Clotted blood: 5ml Clot activator and separation gel (GOLD CAPPED) container.

Molecular
EDTA: 4ml blood into a EDTA (LAVENDER CAPPED) container.
CSF: Collect at least 0.2ml using the CSF sample collection kit if available. A sterile container is a suitable alternative.
Bronchoalveolar lavage: Collected in a sterile leak-proof container.
Tissue: Collected in a sterile leak-proof container.
Urine: Collected in a sterile leak-proof container.
Ideal time to take specimen  
Labelling requirements click here
How to take the specimen  
Transport to the laboratory CMV surveillance samples
A 4ml EDTA (LAVENDER CAPPED) blood should reach the laboratory via the pod system (810) or via the porter. Delivery should be no later than 09:00 hours if a same day result is required. If transport is delayed then store at +4°C
Test Times CMV IgG / Avidity: Daily
CMV IgM: Daily
CMV PCR: Daily
Turnround CMV IgG / Avidity: 3-5 working days
CMV IgM: 3-5 working days
CMV PCR: 2 working days
Additional information  
Additional Examination Requests click here


Back

Laboratory Services Home Page